Adolescents and young adults (AYAs) aged 20–39 account for the steepest increase in the rising rates of early-onset colorectal cancer, but identification of early warning signs and vigilant screening can prevent the predictions of the incidence doubling by 2030 in patients younger than 50 years. According to the results of a new study published in the Journal of the National Cancer Institute, four red flags should trigger clinicians to refer younger individuals for early detection testing.